Cheap Flights From Knoxville To Charleston From | TYS - CHS

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Knoxville to Charleston

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Flight Schedules From Knoxville to Charleston

Last Update: Tue, 02 Jun 2026

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Time Earliest	Depart Earliest	Arrive	Duration	Stopover All	Airline All Airlines	Aircraft All Aircrafts	Availability MTWTFSS
05:17TYS 10:06CHS	4 Hrs,49m 1 Stop (CLT)	American Airlines·CCR7 M T W T F S S	TYS 05:17 - CHS 10:06 4h 49m·1 stop (CLT)	TYS 05:17 CLT 08:55	CLT 06:30 CHS 10:06	4h 49m	1 Stop CLT · 2h 25m	American Airlines American Airlines	CCR7 C738	M T W T F S S
05:17TYS 08:18CHS	3 Hrs,1m 1 Stop (CLT)	American Airlines·CCR7 M T W T F S S	TYS 05:17 - CHS 08:18 3h 1m·1 stop (CLT)	TYS 05:17 CLT 07:10	CLT 06:30 CHS 08:18	3h 1m	1 Stop CLT · 40m	American Airlines American Airlines	CCR7 CCR9	M T W T F S S
05:50TYS 09:55CHS	4 Hrs,5m 1 Stop (IAD)	United Airlines·EERJ M T W T F S S	TYS 05:50 - CHS 09:55 4h 5m·1 stop (IAD)	TYS 05:50 IAD 08:15	IAD 07:33 CHS 09:55	4h 5m	1 Stop IAD · 42m	United Airlines United Airlines	EERJ E319	M T W T F S S
07:11TYS 10:06CHS	2 Hrs,55m 1 Stop (CLT)	American Airlines·EE75 M T W T F S S	TYS 07:11 - CHS 10:06 2h 55m·1 stop (CLT)	TYS 07:11 CLT 08:55	CLT 08:20 CHS 10:06	2h 55m	1 Stop CLT · 35m	American Airlines American Airlines	EE75 E738	M T W T F S S
07:11TYS 12:12CHS	5 Hrs,1m 1 Stop (CLT)	American Airlines·EE75 M T W T F S S	TYS 07:11 - CHS 12:12 5h 1m·1 stop (CLT)	TYS 07:11 CLT 11:00	CLT 08:20 CHS 12:12	5h 1m	1 Stop CLT · 2h 40m	American Airlines American Airlines	EE75 E738	M T W T F S S
09:07TYS 14:14CHS	5 Hrs,7m 1 Stop (CLT)	American Airlines·EER4 M T W T F S S	TYS 09:07 - CHS 14:14 5h 7m·1 stop (CLT)	TYS 09:07 CLT 13:05	CLT 10:25 CHS 14:14	5h 7m	1 Stop CLT · 2h 40m	American Airlines American Airlines	EER4 ECR9	M T W T F S S
09:07TYS 12:12CHS	3 Hrs,5m 1 Stop (CLT)	American Airlines·EER4 M T W T F S S	TYS 09:07 - CHS 12:12 3h 5m·1 stop (CLT)	TYS 09:07 CLT 11:00	CLT 10:25 CHS 12:12	3h 5m	1 Stop CLT · 35m	American Airlines American Airlines	EER4 E738	M T W T F S S
10:16TYS 14:13CHS	3 Hrs,57m 1 Stop (IAD)	United Airlines·EERJ M T W T F S S	TYS 10:16 - CHS 14:13 3h 57m·1 stop (IAD)	TYS 10:16 IAD 12:35	IAD 11:41 CHS 14:13	3h 57m	1 Stop IAD · 54m	United Airlines United Airlines	EERJ EE7W	M T W T F S S
11:06TYS 15:52CHS	4 Hrs,46m 1 Stop (DCA)	American Airlines·EE75 M T W T F S S	TYS 11:06 - CHS 15:52 4h 46m·1 stop (DCA)	TYS 11:06 DCA 14:14	DCA 12:48 CHS 15:52	4h 46m	1 Stop DCA · 1h 26m	American Airlines American Airlines	EE75 EE75	M T W T F S S
11:08TYS 14:14CHS	3 Hrs,6m 1 Stop (CLT)	American Airlines·EER4 M T W T F S S	TYS 11:08 - CHS 14:14 3h 6m·1 stop (CLT)	TYS 11:08 CLT 13:05	CLT 12:25 CHS 14:14	3h 6m	1 Stop CLT · 40m	American Airlines American Airlines	EER4 ECR9	M T W T F S S
14:20TYS 18:54CHS	4 Hrs,34m 1 Stop (IAD)	United Airlines·EERJ M T W T F S S	TYS 14:20 - CHS 18:54 4h 34m·1 stop (IAD)	TYS 14:20 IAD 17:10	IAD 15:50 CHS 18:54	4h 34m	1 Stop IAD · 1h 20m	United Airlines United Airlines	EERJ EE7W	M T W T F S S
14:25TYS 17:14CHS	2 Hrs,49m 1 Stop (CLT)	American Airlines·EER4 M T W T F S S	TYS 14:25 - CHS 17:14 2h 49m·1 stop (CLT)	TYS 14:25 CLT 16:15	CLT 15:40 CHS 17:14	2h 49m	1 Stop CLT · 35m	American Airlines American Airlines	EER4 E320	M T W T F S S
14:25TYS 19:02CHS	4 Hrs,37m 1 Stop (CLT)	American Airlines·EER4 M T W T F S S	TYS 14:25 - CHS 19:02 4h 37m·1 stop (CLT)	TYS 14:25 CLT 18:00	CLT 15:40 CHS 19:02	4h 37m	1 Stop CLT · 2h 20m	American Airlines American Airlines	EER4 E320	M T W T F S S
16:09TYS 21:30CHS	5 Hrs,21m 1 Stop (CLT)	American Airlines·EER4 M T W T F S S	TYS 16:09 - CHS 21:30 5h 21m·1 stop (CLT)	TYS 16:09 CLT 20:20	CLT 17:25 CHS 21:30	5h 21m	1 Stop CLT · 2h 55m	American Airlines American Airlines	EER4 ECR9	M T W T F S S
16:09TYS 19:02CHS	2 Hrs,53m 1 Stop (CLT)	American Airlines·EER4 M T W T F S S	TYS 16:09 - CHS 19:02 2h 53m·1 stop (CLT)	TYS 16:09 CLT 18:00	CLT 17:25 CHS 19:02	2h 53m	1 Stop CLT · 35m	American Airlines American Airlines	EER4 E320	M T W T F S S

05:17TYS

10:06CHS

4 Hrs,49m

1 Stop (CLT)

American Airlines·CCR7

05:17TYS

08:18CHS

3 Hrs,1m

1 Stop (CLT)

American Airlines·CCR7

05:50TYS

09:55CHS

4 Hrs,5m

1 Stop (IAD)

United Airlines·EERJ

07:11TYS

10:06CHS

2 Hrs,55m

1 Stop (CLT)

American Airlines·EE75

07:11TYS

12:12CHS

5 Hrs,1m

1 Stop (CLT)

American Airlines·EE75

09:07TYS

14:14CHS

5 Hrs,7m

1 Stop (CLT)

American Airlines·EER4

09:07TYS

12:12CHS

3 Hrs,5m

1 Stop (CLT)

American Airlines·EER4

10:16TYS

14:13CHS

3 Hrs,57m

1 Stop (IAD)

United Airlines·EERJ

11:06TYS

15:52CHS

4 Hrs,46m

1 Stop (DCA)

American Airlines·EE75

11:08TYS

14:14CHS

3 Hrs,6m

1 Stop (CLT)

American Airlines·EER4

14:20TYS

18:54CHS

4 Hrs,34m

1 Stop (IAD)

United Airlines·EERJ

14:25TYS

17:14CHS

2 Hrs,49m

1 Stop (CLT)

American Airlines·EER4

14:25TYS

19:02CHS

4 Hrs,37m

1 Stop (CLT)

American Airlines·EER4

16:09TYS

21:30CHS

5 Hrs,21m

1 Stop (CLT)

American Airlines·EER4

16:09TYS

19:02CHS

2 Hrs,53m

1 Stop (CLT)

American Airlines·EER4

The most popular airline flying from Knoxville to Charleston is American Airlines. Find the latest flight deals on Wego.

The flight distance between Knoxville and Charleston is 509km. Check all available flights on Wego.

The earliest flight of the day departs at 05:17. The last flight of the day departs at 20:48. See the full list of flight times on Wego.